Will labetalol harm my baby?
Use of labetalol in pregnancy is common and there is no concern that it causes harm. Labetalol belongs to a family of medicines called beta blockers. Studies have not shown that beta blockers cause birth defects, stillbirth, or preterm birth. Women taking beta blockers may be more likely to have a small baby.
How much labetalol is safe during pregnancy?
In severe refractory hypertension, daily doses of up to 2400 mg have been given, divided into three or four times a day regimens. Hypertension in Pregnancy: An initial dosage of 100 mg twice daily may be increased, if necessary at weekly intervals by 100 mg twice daily.
Does labetalol affect fetal heart rate?
drug RCTs, neonatal bradycardia was not observed (0/24 vs. 0/26). Conclusions: Available data are inadequate to conclude whether oral methyldopa, labetalol, nifedipine, or hydralazine adversely affect fetal or neonatal heart rate and pattern.
Does labetalol cross the placenta?
Labetalol Pregnancy Warnings
During the final part of pregnancy and parturition these drugs should therefore only be given after weighing the needs of the mother against the risk to the fetus. -This drug crosses the placental barrier and has been found to bind to the eyes of fetal animals.
Why labetalol is safe in pregnancy?
Labetalol works as well as other beta blockers for reducing blood pressure, but it starts working more quickly. If you’re pregnant, labetalol is the first choice for treating high blood pressure. Labetalol works on the heart and on blood vessels.
When should you not take labetalol?
You should not use labetalol if you are allergic to it, or if you have: asthma; “AV block” (2nd or 3rd degree);
Can labetalol cause miscarriage?
Does taking labetalol increase the chance of miscarriage? Miscarriage can occur in any pregnancy. It is not known if labetalol increases the chance of miscarriage.
How quickly does labetalol work?
Labetalol starts to work within 2 hours, but it can take a few days to take full effect. You may not feel any different when you take labetalol, but this doesn’t mean it’s not working.
How much does labetalol lower BP?
Response and effectiveness
Blood pressure-lowering effects increase with higher dosages. An average lowering of blood pressure of 11/7 mmHg was reported with an initial dosage of 0.25 mg/kg labetalol injection. Blood pressure-lowering effects last an average of 16 to 18 hours.
Is labetalol hard on the kidneys?
Acute renal failure is uncommon in pure beta adrenergic blocker toxicity, but labetalol, with its alpha blockade, can lead to complex hemodynamic changes and can cause acute renal failure at toxic levels.
What can you not take with labetalol?
Labetalol may interact with other medications
- Drugs used to treat depression. Taking labetalol with a tricyclic antidepressant may increase your risk of tremors. …
- Asthma inhalers. Taking labetalol may cause narrowing of your airways. …
- Heartburn medications. …
- Heart medications.
What is the safest blood pressure medicine during pregnancy?
Methyldopa has been used for decades to treat high blood pressure in pregnancy and it appears to be safe. Labetalol has been extensively studied and has become increasing prescribed in pregnancy. Labetalol is now commonly used as a first-line treatment choice.